Zoloft Price Guide: What You Pay and How to Save

If you’re looking at Zoloft (sertraline) prescriptions, the first thing that pops into your mind is usually the price tag. Prices can swing wildly depending on where you shop, whether you have insurance, and if you pick a brand or generic version.

Typical Zoloft Costs in 2025

In the U.S., a 30‑day supply of brand‑name Zoloft 50 mg usually runs between $150 and $250 without insurance. The generic sertraline, which is chemically identical, typically costs $15‑$45 for the same amount. In the UK, a 28‑day pack of generic sertraline can be as low as £5 if you use the NHS, but private pharmacies may charge £12‑£20.

Canada and Australia see similar gaps: brand Zoloft may hit $200 CAD, while generic sertraline sits around $30‑$60. Remember that these numbers shift with market changes, so it’s smart to check the latest pharmacy listings before you buy.

How to Cut Your Zoloft Bill

1 Use a generic. Most doctors will write sertraline unless there’s a specific reason to stay on brand. The effect is the same, but the price difference is huge.

2 Shop around. Online pharmacies often list lower prices than brick‑and‑mortar stores. Look for licensed sites that require a prescription and compare at least three offers.

3 Check discount cards. Many pharmacy chains hand out savings cards that shave 10‑20% off the retail price. Some third‑party programs, like GoodRx in the U.S., can lower costs even more.

4 Ask about bulk prescriptions. A 90‑day supply usually costs less per month than a 30‑day refill, especially if your insurer covers part of it.

5 Use insurance wisely. If you have prescription coverage, make sure Zoloft is on the formulary. Sometimes switching to a different dosage or tablet size can move the drug into a lower co‑pay tier.

6 Explore patient assistance programs. The manufacturer of brand Zoloft runs a limited‑time assistance program for people without insurance. Eligibility checks are quick, and you could get the medication for free or at a reduced price.

7 Consider mail‑order services. Many health plans offer cheaper rates when you order your meds through their mail‑order pharmacy. Delivery is usually within a week, and you avoid extra trips to the store.

By mixing these tactics—generic choice, price comparison, discount cards—you can often bring a $150 brand price down to under $30.

Keep in mind that price shouldn’t be your only factor. Always talk to your doctor before switching brands or dosages, and make sure any online pharmacy you use is properly accredited. With a bit of effort, paying for Zoloft doesn’t have to break the bank.